Nanobiotechnology : Syllabus

Shubham Thorat
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UNIT-I

1) Introduction to nanotechnology:

    a. Milestones in Nanotechnology 

    b. effect of length scale on properties.

    c. Overview of nanoscale material

    d. Top-down and bottom-up approach of nanoparticle synthesis

    e. Challenges and opportunities associated with nanoscale materials



2) Concepts and Terminology:

    a. List of terms used in a field



3) Nano-Bio Interface:

    a. Introduction, colloidal forces as well as dynamic biophysicochemical interactions

    b. Designing of nanobiointerface

    c. Biocompatible or bio adverse outcomes and applications



4) Biological based Nano systems:

    a. Introduction

    b. Butterfly wings

    c. Lotus effect



5) Molecular motors:

    a. Introduction

    b. Life is Motion

    c. Cytoskeleton system

    d. Applications of molecular motor in Nanotechnology.



6) Biosensors:

    a. Definition, components, Principles of detection

    b. Using Antibodies in Biosensors

    c. Immunoassays, Cantilevers as Nano-Biosensors

    d. Micro- and Nano sensors and Applications of Optical Nano sensors.



7) Other devices:

    a. Types-

        i) solid state devices (CMOS, quantum)

        ii) molecular devices (electrochemical, electromechanical, photoactive, quantum)

    


UNIT-I


1) Self assembly of molecules for nanotechnology applications:

    a. Introduction

    b. mechanism of self assembly:

        i) Self Assembly by Molecular Interactions- 

            - intermolecular interaction

            - Hamaker interaction, and 

            - some examples of self assembly

        ii) Externally Directed Self Assembly-

            - electric and magnetic 

            - field, flow field, 

            - microscopic viscous flow, 

            - large amplitude oscillatory shear (LAOS), 

            - combination of fields.

   


2) Biomimetics:

    a. Biomimetic Design of Molecules

    b. Some Key Principles of Biological Self-Assembly in nanotechnology

    c. Biomimetic Nanomaterials- nanotubes, nanofibers etc.



3) Biomimetic Nanoengineering:

    a. Nano-engineering of Colloidal Particles

    b. Antigen presenting cells

    c. Synthetic Biomimetic Blood Cells, etc.



4) Biotemplating:

    a. Definition, mechanism, materials, advantages, limitations, future perspectives



5) de novo designed nanostructures and materials:

    a. De Novo Designed α-Helix Coiled-Coil Nanofibers



6) DNA-Nanotechnology:

    a. Introduction, History, 

    b. DNA nanostructure;

    c. Capabilities, possibilities and limitation of DNA nanostructure

    d. DNA origami. Applications of DNA nanotechnology



7) Nanomanipulations:

    a. Introduction

    b. Types-

        i) AFM

        ii) STM

    c. In situ SEM manipulation

    d. In situ TEM manipulation



8) Material design: Techniques:

    a. Techniques



9) Nanomaterial synthesis:

    a. Physical method

        i) Mechanical-high energy ball milling

        ii) Melt mixing

        iii) Vapour-physical vapour deposition,

        iv) Laser ablation

        v) Sputter deposition

        vi) Electric arc deposition

        vii) Ion implantation

    b. Chemical method

        i) collide

        ii) sol gel method

    c. Biological method

        i) Green synthesis by microorganisms, fungi, plant extracts

    d. Advantages and drawbacks of each method.



10) Applications of Nanotechnology:

    a. Application of nanotechnology in Medical

    b. Application of nanotechnology in Agriculture and food

    c. Application of nanotechnology in space

    d. Application of nanotechnology in Defense and Engineering

    e. Application of nanotechnology in Domestic appliances

    f. Application of nanotechnology in cosmetics

    g. Application of nanotechnology in textiles

    h. Application of nanotechnology in automobiles

    i. Application of nanotechnology in energy



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